请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Reaction Biology/BRD3-2 (GST)/RD-11-164
产品编号:RD-11-164
市  场 价:¥6400.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$320.00
品      牌: Reaction Biology
公      司:Medical Device Depot
公司分类:
Reaction Biology/BRD3-2 (GST)/RD-11-164
商品介绍

DESCRIPTION:Human recombinant BRD3, bromodomain-2 expressed as an N-terminal GST fusion protein. BRD3, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD4, BRDT), comprises two bromodomains, protein modules that bind epsilon-N-acetyllysine residues. Recent results suggest an important role for BRD3 in linking acetylation of both histones and non-histone proteins to gene transcription. When overexpressed in 293 cells, BRD3, along with BRD2, binds the hyperacetylated chromatin of transcribed genes, regions enriched in acetylated histone H4 lysine-5 (H4K5Ac), H4K12Ac, H3K14Ac, but deficient in H4K16Ac and H3K9me. In an in vitro RNA polymerase II transcription system, binding of either BRD3 or BRD2 to a chromatin template assembled with hyperacetylated histones enabled transcription through the nucleosomes. In addition to acetylated histones, BRD3-1 (BRD3 bromodomain 1) has been found to bind the hematopoietic transcription factor GATA1 and to enhance its chromatin binding and activation of target genes. The BET family inhibitor, I-BET151, has shown efficacy in mouse models of MLL-fusion leukemias, displacing BRD3 and BRD4 from chromatin and inhibiting transcription of genes, e.g. BCL2, upregulated by the MLL-fusions.

ACCESSION #: NM_007371

Uniprot Link

INCLUDES AMINO ACIDS: 306-416

TAG(S): GST

MW: 40.1 kDa

EXPRESSION SYSTEM: E. coli

SUPPLIED AS: Solution of purified recombinant protein in 20 mM Tris/HCl, pH 7.5, 150 mM NaCl, 1.0 mM TCEP, 10% glycerol (w/v).

STORAGE: -80°C, aliquot and snap-freeze after first use.

View Product Data Sheet

Substantial Discounts Available on Bulk Quantities

We also offer assay services for BRD3-2 (GST).

品牌介绍

Medical Device Depot,Inc.(MDD)的成立基于一个简单的想法:改变全球医疗保健专业人员购买其医疗设备的方式。

许多医疗设备供应商的员工常常缺乏充分满足客户需求并回答所有问题所需的培训和知识。对于繁忙的医师和其他寻求购买优质医疗设备的医疗保健专业人员而言,结果通常是一个缓慢,麻烦且令人沮丧的过程。

医疗器械仓库有所不同。我们经验丰富的销售和服务代表经过全面培训,可以回答您有关我们广泛目录中产品的所有问题。我们的首要任务是确保您对每次购买都充满信心。我们致力于为您提供无忧的愉快体验。

使用医疗设备仓库时,您可以期望得到以下结果:

  • 来自礼貌,知识渊博的代表的个性化服务-您将永远不会使用机器。

  • 如果您的代表在呼叫时与另一个客户一起工作,则在一个小时内返回的呼叫。

  • 每次互动中的诚实和透明。


我们珍惜您的时间,并了解购买医疗设备时您有很多选择。医疗器械仓库保证了响应,高效,周到的服务,这是我们对您的承诺。我们期待着帮助您满足所有医疗设备需求。

自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔